Profhilo (standard hi + lo MW HA)
2 sessions 4 weeks apart at the BAP-9 grid. 64mg HA per 2ml syringe. SGD 1,000 per session. The market-recognised name in Singapore.
PROFHILO + THE BIOREMODELLER ALTERNATIVES SAM CONSIDERS
Wondering if Profhilo actually delivers the skin glow it's known for?
Dr Samantha picks between Profhilo and Jalupro on assessment, not on brand recognition. Both are HA-based and reversible with hyaluronidase if response is uneven. Most patients see skin-quality response four to six weeks after the second session, lasting four to six months.
From SGD 1,000 per session
TREATMENT MENUSGD 1000SGD 1000SGD 1000
Pricing for every variant.
Profhilo 2ml
Juvederm SkinViv 1ml
Jalupro (higher-HA alternative)
Bioremodeller variants Dr Samantha offers at Nexus
How Profhilo works as a hyaluronic acid bioremodeller
Profhilo is a NAHYCO-stabilised hyaluronic acid bioremodeller. The formulation combines high molecular weight HA and low molecular weight HA in a single 2ml syringe. Total HA per syringe is 64mg. The hi + lo combination is what differentiates this bioremodeller from standard HA filler.
- High MW HA: hydrates and supports the dermal layer. Acts as a moisture reservoir for the surrounding tissue.
- Low MW HA: signals fibroblast activity. Stimulates collagen and elastin response over the 4 to 6 week window after each session.
- BAP-9 placement: the bioremodeller is injected at 5 standardised points across each cheek + jawline (10 points total). The injection spreads spontaneously between points across 24 to 48 hours.
- 2-session course: the standard protocol is 2 sessions 4 weeks apart. Reassess maintenance around month 6.
It does not change face shape. It is a hydration + skin-quality protocol, not a volumiser. Patients seeking volume should consider HA fillers or microsphere stimulators (offered elsewhere, not at Nexus per Dr Samantha's collagen-stimulator protocol preference).
Which Profhilo and biostimulator protocols Nexus offers
Dr Samantha also offers Jalupro, a higher-HA bioremodeller alternative (80mg HA, plus amino acids and peptides). Jalupro has more HA per syringe (80mg vs the bioremodeller's 64mg) and adds amino acid and peptide layers that this product does not. Profhilo has been in the Singapore market longer, so its name recognition is higher. Both are offered. The choice happens at consultation based on what the dermal assessment shows.
Dr Samantha's bioremodeller framework
My bioremodeller decision starts with the dermal assessment, not the brand name on the syringe. I run three pathways depending on what the skin asks for.
- Standard path: 2 sessions 4 weeks apart at the BAP-9 grid. I default here when the read calls for layered high and low molecular weight hyaluronic acid.
- Jalupro path: higher HA content with amino acids and peptides. I move to this when the patient wants a multi-component bioremodeller layer rather than pure HA.
- Juvederm SkinViv (formerly Volite) path: single-session resilient HA microdroplet booster. I pick this when the patient prefers fewer visits; the FDA SSED supports review at 4 to 8 weeks.
Who a bioremodeller suits and who does not
Suitable for
Suitable for
- Skin-quality concerns: dehydration, fine surface lines, dull tone, loss of bounce in the cheek and jawline.
- Patients in their late 20s through 50s wanting maintenance rather than volume change.
- Patients comfortable with a 2-session commitment 4 weeks apart, with results visible 4-6 weeks after session 2.
- Patients open to the Jalupro alternative at consultation if the assessment supports it.
Take care
Pause first
- Patients seeking volume change or face-shape change. Profhilo does not volumise. Filler or stimulator pathways apply instead.
- Patients with active inflammatory acne or skin infections at the BAP-9 zones. Settle the skin first.
- Patients expecting same-day visible results. The bioremodeller response builds over 4-6 weeks after session 2.
- Patients with a documented HA-product hypersensitivity history. Discuss with Dr Samantha first.
What a bioremodeller session at Nexus involves, step by step
- Step 1, 10 min
Skin assessment + protocol confirm
Dr Samantha reviews dermal hydration, surface texture, prior bioremodeller or filler history. Confirms Profhilo vs Jalupro vs SkinViv pathway.
- Step 2, 5 min
Numbing cream + skin prep
Topical anaesthetic across the BAP-9 zones on both cheeks and the jawline. Skin cleaned with sterile prep.
- Step 3, 15-20 min
BAP-9 injection
Profhilo placed at 5 points per cheek + jawline zone (10 total). Fine needle, minimal discomfort. Spontaneous spread happens over the next 24-48 hours.
- Step 4, 5 min
Cool down + aftercare brief
Cool compress on injection points. Dr Samantha walks through 48-hour aftercare and the session-2 booking 4 weeks out.
Profhilo sessions, pacing, and how long results actually last
Profhilo course at Nexus
| Concern | Typical sessions | Interval | Duration of results |
|---|---|---|---|
| First-time bioremodeller course | 2 sessions | 4 weeks apart | Result visible 4-6 weeks after session 2; lasts 4-6 months |
| Maintenance (after first course) | 1-2 per cycle | Every 6 months | Reassess at month 6 based on response |
| Combined with skin booster | Profhilo + booster combo | Different days, 2-week gap | Combined hydration + glow effect |
| Jalupro alternative | 2-3 sessions | 3-4 weeks apart | Comparable duration, multi-component layer |
Cadence is matched to skin response, not a fixed package. Individual results vary.
Bioremodeller side effects and recovery to expect
Worth knowing
Common (most patients)
- Small bumps at each injection point for 24 to 48 hours as the bioremodeller spreads spontaneously across the BAP-9 zones.
- Mild redness for 30 to 60 minutes post-session at the cheek and jawline zones.
- Mild tenderness at injection points for 24 hours.
Take care
Less common
- Localised bruising at one or two BAP-9 points, resolving within 5 to 7 days.
- Mild swelling extending beyond 48 hours. Escalate to Dr Samantha if persists past day 3.
- Rare hypersensitivity reaction. HA-based products are hyaluronidase-reversible if needed.
Profhilo pricing context in Singapore
Profhilo pricing in Singapore sits in the SGD 900 to SGD 1,200 per 2ml session band, with most clinics running a two-session protocol four weeks apart. Current per-session pricing at Nexus is shown in the treatment menu above. Bioremodellers are not Medisave-claimable in Singapore.
Aftercare for a bioremodeller session
- Day 0 to 2
Settle the BAP-9 points
Avoid pressure on the cheek and jaw zones for 24 hours. No facials, no makeup over injection points for 12 hours. Cool compress for 10 minutes if any tenderness.
- Day 0 to 7
Restore the barrier
Sun protection (SPF 50) daily. Hyaluronic acid + ceramide moisturiser. Avoid retinoids, vitamin C serums, and exfoliants for 7 days.
- Week 4 onward
Session 2 at week 4
Book session 2 four weeks after session 1. Results become visible 4 to 6 weeks after session 2.
Esther sends a brief aftercare summary via WhatsApp post-session.
Why this bioremodeller sits in Dr Samantha's stack
- HA-based reversibility: hyaluronidase reverses Profhilo if response is uneven. Microsphere stimulators do not offer this.
- Skin-quality outcome: improves dermal hydration, surface texture, and bounce without changing face shape.
- Two-session course with a defined endpoint: not a permanent treatment, not an open-ended package. Reassess at month 6.
- Jalupro discussed at consultation: patients who want the multi-component layer (amino acids + peptides) have an alternative.
- Combinable with skin boosters (SkinViv, Filorga NCTF 135 HA, K-Glass) on different visits for a layered protocol.
Common questions before booking
YOUR CONSULTATION
One assessment with Dr Samantha.
Twenty minutes with Dr Samantha. Consultation SGD 80, fully credited toward any treatment that follows.
111 Somerset Road, #03-19, TripleOne Somerset, Singapore 238164
Mon to Fri 10am to 8pm · Sat 10am to 5pm · Sun closed