Profhilo (2-session bioremodeller)
Hi + lo MW hyaluronic acid bioremodeller. 2 sessions 4 weeks apart on the BAP-9 cheek + jaw grid. Reviews maintenance around month 6. SGD 1,000 per session.
FOR PATIENTS CONSIDERING SCULPTRA, ELLANSE, OR RADIESSE
Want collagen stimulators without PLLA risks? Dr Samantha picks hyaluronic acid biostimulators instead.
Crepey texture needs more than a brand name. Dr Samantha checks skin quality first, then explains whether collagen stimulators or hydrating boosters fit.
From SGD 480
TREATMENT MENUSGD 480SGD 480SGD 600SGD 800SGD 1000SGD 1000
Pricing for every variant.
Chanel Filorga NCTF 135 HA
K-Glass Skin
Teosyal Redensity 1 (1ml)
Nucleofill Strong (1.5ml)
Profhilo (2ml)
Juvederm SkinViv (1ml)
Collagen biostimulator types offered at Nexus
How collagen-stimulating injectables work in the dermis
Collagen stimulators sit in two broad mechanistic categories. The first uses microspheres of inert materials (PLLA in Sculptra, PCL in Ellanse, CaHA in Radiesse) that scaffold the dermis and trigger fibroblasts to lay down new collagen over months. The second uses hyaluronic acid bioremodellers (Profhilo's high + low molecular weight HA, Juvederm SkinViv, Teosyal Redensity 1, Filorga NCTF 135 HA, K-Glass) that hydrate the dermis and stimulate a more conservative collagen response while remaining hyaluronidase-reversible.
- PLLA microspheres (Sculptra): poly-L-lactic acid framework triggers gradual collagen synthesis over 3 to 6 months. Result is delayed but lasts up to 2 years. Microsphere-based, not enzymatically dissolvable.
- PCL microspheres (Ellanse): polycaprolactone scaffold with immediate HA-gel filler vehicle. Volume effect is immediate; collagen-stim effect lasts 2 to 3 years depending on Ellanse subclass. Also microsphere-based, also not enzymatically reversible.
- CaHA microspheres (Radiesse): calcium hydroxylapatite spheres in HA gel carrier. Immediate volume + collagen response, 12 to 18 months duration. Not enzymatically reversible.
- HA bioremodellers (Profhilo, NAHYCO-stabilised hi+lo MW): act as a hydration-and-bioremodelling skin booster. Reversible with hyaluronidase if needed. Effect: 4 to 6 weeks after the 2nd session, maintained 4 to 6 months.
- HA skin boosters (SkinViv, Teosyal Redensity 1, NCTF 135 HA, K-Glass): different HA formulations placed at variable dermal depths. Surface glow + dermal hydration. Effect onset 2 to 4 weeks. Hyaluronidase-reversible.
Both categories stimulate collagen. The trade-off is permanence vs reversibility, onset speed vs lasting volume, and known short-term safety profile vs long-term microsphere behaviour. Dr Samantha's protocol begins with the reversible category.
Which collagen stimulators Nexus offers and which we deliberately do not
The page above the fold already names the products Nexus does not offer. Below is the full picture. Dr Samantha's protocol selection is based on the reversibility and known short-term safety profile of HA-based biostimulators, not on a claim that microsphere stimulators are unsafe in trained hands.
Why Dr Samantha's HA-first framework leads her collagen protocol
For patients seeking skin-quality support at Nexus, Dr Samantha's protocol starts with one of three HA-based pathways before considering microsphere stimulators offered elsewhere.
- Bioremodeller path (Profhilo): 2 sessions, 4 weeks apart. Hi + lo MW hyaluronic acid placed at the BAP-9 grid on cheek + jawline. Reviews maintenance around month 6.
- Surface-glow path (SkinViv, NCTF 135 HA, K-Glass): single-session HA boosters at variable dermal depth. SkinViv reviewed at 4 to 8 weeks; reassesses around month 6 to 9.
- Multi-ingredient path (Teosyal Redensity 1, Filorga NCTF 135 HA): HA combined with amino acids, peptides, minerals. 2 to 3 sessions, 4 to 6 weeks apart.
- Polynucleotide alternative (Nucleofill, Rejuran): different mechanism class, also reversible safety profile. Cross-linked to /rejuran-polynucleotide-skinbooster.
Every path keeps adjustment open. If response is uneven, hyaluronidase reverses HA-based biostimulators. Polynucleotide options metabolise naturally over weeks. The framework picks reversibility first.
Who suits HA biostimulators for collagen and who does not
Honest filter before the consultation. If you are in the right group, the next session is a 20-minute assessment with Dr Samantha. If you are in the wrong group, she will say so and route accordingly.
Suitable for
Suitable for HA biostimulators
- Mild to moderate dermal dehydration, fine lines, or surface dullness
- Patients who want a reversible biostimulator if response is uneven
- Patients in their late 20s to 60s with healthy skin barrier
- Patients who have tried surface skincare and want a dermal-layer step
- Patients seeking maintenance every 4 to 9 months, not a one-shot fix
Suitable for
Pause first / route elsewhere
- Active acne flare, untreated rosacea, or open dermatitis on injection zone
- Patients seeking immediate visible volume restoration (HA boosters do not bulk fill, see dermal fillers instead)
- Patients with a history of HA hypersensitivity or recent hyaluronidase reaction
- Pregnancy or breastfeeding
- Patients wanting long-duration framework volume (Dr Samantha will discuss what's available elsewhere)
The 20-minute consultation with Dr Samantha is SGD 80 and fully credited toward any treatment.
What a Profhilo or HA biostimulator collagen session at Nexus involves
Most HA-biostimulator sessions at Nexus run 30 to 45 minutes from check-in to walking out. Below is the typical Profhilo flow; SkinViv, NCTF 135 HA, and K-Glass follow a similar arc with different injection patterns.
- Step 1, 10 min
Diagnostic + skin map
Dr Samantha reviews dermal hydration, laxity zones, and prior skin-booster history. Confirms HA biostimulator is the right next step or routes elsewhere.
- Step 2, 5 min
Numbing cream + skin prep
Topical anaesthetic on the BAP-9 injection grid for Profhilo, or surface microdroplet zones for SkinViv. Skin cleaned with sterile prep.
- Step 3, 15-20 min
Injection
Profhilo placed at 5 BAP-9 points per cheek + jaw zone. SkinViv placed as fine microdroplets at the surface dermal layer. Minimal discomfort, fine needle.
- Step 4, 5 min
Cool down + aftercare brief
Cool compress on injection points. Dr Samantha walks through 48-hour aftercare + when to return for session 2 (Profhilo) or 4-8 week review (SkinViv).
Total chair time: 35-40 minutes per session. Most patients return to work the same day.
Collagen biostimulator sessions and review timeline per variant
HA biostimulator pacing
| Variant | Sessions | Interval between sessions | Typical review window |
|---|---|---|---|
| Profhilo (2ml) | 2 sessions | 4 weeks apart | Reassess around month 6 |
| Juvederm SkinViv (1ml) | 1 session | Touch-up optional at 4-8 weeks | Reassess around month 6 to 9 |
| Teosyal Redensity 1 | 2-3 sessions | 4-6 weeks apart | Reassess around month 6 |
| Filorga NCTF 135 HA | 3-4 sessions | 2-4 weeks apart | Reassess around month 6 |
| K-Glass Skin | 3 sessions | 4 weeks apart | Reassess around month 6 |
Pacing is the published protocol or FDA SSED for each product. Dr Samantha reviews response during the course. Individual results vary.
Collagen biostimulator side effects and recovery to expect
Side effects for HA biostimulators are typically mild and short-lived. The reversibility of HA is the key safety differentiator from microsphere stimulators.
Suitable for
Common (90-95% of patients)
- Mild redness at injection points for 24 to 48 hours
- Small bumps or wheals from the HA depot, settling over 24 to 72 hours
- Minor bruising at one or two injection points, resolves within a week
- Slight tenderness, settles within 24 hours
Suitable for
Rare (under 5%)
- Hypersensitivity reaction to the HA carrier (managed with antihistamine or hyaluronidase reversal)
- Persistent nodule at an injection point (rare with HA biostimulators, more common with microsphere stimulators)
- Vascular event (very rare with skin-depth biostimulators, more relevant to volumetric filler placement)
Dr Samantha reviews complete contraindications at consultation. Any unexpected swelling, severe pain, or vision change after injection warrants same-day callback.
Collagen stimulator pricing context in Singapore
Hyaluronic acid biostimulator pricing in Singapore sits in the SGD 480 to SGD 1,000 per session range, depending on volume and formulation. Current per-session pricing at Nexus is shown in the treatment menu above. Aesthetic injectables are not Medisave-claimable in Singapore.
Aftercare for a collagen biostimulator session
- Day 0 to 2
Settle the injection points
Avoid pressure on the cheek + jaw zones for 24 hours. No facials, no make-up over injection points for 12 hours. Cool compress for 10 minutes if any tenderness.
- Day 0 to 7
Restore the barrier
Sun protection (SPF 50) daily. Hyaluronic acid + ceramide moisturiser. Avoid retinoids, vitamin C serums, and active exfoliants for 7 days.
- Week 1 and beyond
Daily care matters more than any single product
Continue daily SPF + barrier moisturiser. Schedule session 2 at week 4 for Profhilo. Review at week 4 to 8 for SkinViv.
Photo comparison at session 2 (Profhilo) or review (SkinViv) confirms the response Dr Samantha is tracking.
Why HA biostimulators sit above microsphere collagen stimulators in Dr Samantha's protocol
- Reversibility: hyaluronidase reverses HA-based biostimulators if response is uneven, an option that does not exist with microsphere stimulators.
- Conservative onset: 2 to 8 weeks for visible response on most HA boosters, compared to 3 to 6 months for PLLA-driven collagen.
- Doctor-delivered: every HA biostimulator session at Nexus is performed by Dr Samantha, never delegated to a trained therapist.
- Tracked: photo comparison at session 2 (Profhilo) or 4-8 week review (SkinViv) confirms cumulative response.
- Lower nodule profile: HA-depot biostimulators have a lower nodule / granuloma profile than microsphere stimulators per FDA postmarket data.
- Cross-link flexibility: response uneven? Move to a polynucleotide alternative (Rejuran, Nucleofill) on /rejuran-polynucleotide-skinbooster, or to volumetric filler on /dermal-fillers.
Common collagen biostimulator questions before booking
YOUR CONSULTATION
One assessment with Dr Samantha.
Twenty minutes with Dr Samantha. Consultation SGD 80, fully credited toward any treatment that follows.
111 Somerset Road, #03-19, TripleOne Somerset, Singapore 238164
Mon to Fri 10am to 8pm · Sat 10am to 5pm · Sun closed